The chemistry of xanthine oxidase. 5. Electron-spin resonance of xanthine oxidase solutions*
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چکیده
منابع مشابه
The chemistry of xanthine oxidase. Electron-spin resonance of xanthine oxidase solutions.
The participation of metals in the action ofmetalloflavoproteins is the subject of much controversy, and it has recently been concluded by Singer & Massey (1957) that only for nitrate reductase has strong evidence been presented for valency changes in the metal in the course of the enzymic reactions. Studies on the function of the molybdenum, iron and flavinadenine dinucleotide of xanthine oxid...
متن کاملXanthine oxidase: introductory remarks.
At the 661st Meeting of the Biochemical Society, held at Bath, the Host Colloquium, a joint meeting with the Society for Free Radical Research, took place on 10th and 11th April 1997. Its title was ‘Xanthine oxidase: enzymology and pathophysiology’. The two aspects of xanthine oxidase research specified in the Colloquium title have developed remarkably separately, and, for a number of reasons, ...
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In the course of investigations regarding the effects of various chemical agents on neoplast,ic purine metabolism, it was observed that hydroxylamine prevents the accumulation of uric acid or allantoin that normally occurs upon incubation of crude tissue homogenates. Subsequent studies, reported in this paper, demonstrate that hydroxylamine is a competitive inhibitor of xanthine oxidase activit...
متن کاملThe species distribution of xanthine oxidase.
1. The distribution of xanthine oxidase in blood and tissues of various animals was studied by means of a radioactive assay capable of detecting 10(-7) unit of enzyme. The method was shown to be applicable to tissues with a high uricase content. 2. Of 16 mammalian species examined, six had low concentrations of xanthine oxidase in the serum. In six non-mammalian species, no activity was detecte...
متن کاملThe composition of milk xanthine oxidase.
The composition of milk xanthine oxidase has been reinvestigated. When the enzyme is prepared by methods that include a selective denaturation step in the presence of sodium salicylate the product is obtained very conveniently and in high yield, and is homogeneous in the ultracentrifuge and in recycling gel filtration. It has specific activity higher than previously reported preparations of the...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1959
ISSN: 0306-3283
DOI: 10.1042/bj0730193